DO OSSO À PELE
UMA VISÃO CONTEMPORÂNEA DO ENVELHECIMENTO FACIAL E SUAS IMPLICAÇÕES CLÍNICAS
DOI:
https://doi.org/10.5281/zenodo.22166581Palavras-chave:
Envelhecimento facial, Anatomia, Face, Tecido adiposo, Esqueleto facial, Pele, Rejuvenescimento facialResumo
Introdução: O envelhecimento facial é um processo progressivo, heterogêneo e tridimensional, determinado pela interação entre esqueleto facial, compartimentos adiposos, sistema ligamentar, musculatura mimética e pele. A compreensão contemporânea substituiu a interpretação exclusivamente gravitacional por modelos anatômicos integrados, com implicações diretas no planejamento de procedimentos cirúrgicos e minimamente invasivos. Objetivo: Revisar, de forma narrativa, os principais mecanismos anatômicos e fisiopatológicos do envelhecimento facial, preservando uma abordagem estratificada dos planos profundos aos superficiais e discutindo suas implicações clínicas e terapêuticas na interface entre HOF, CEOF e CTBMF. Métodos: Foram analisados estudos clássicos e contemporâneos sobre envelhecimento facial, anatomia em camadas, remodelamento ósseo, compartimentalização adiposa, sistemas de retenção, musculatura mimética, biomecânica facial, envelhecimento cutâneo e modalidades terapêuticas aplicáveis à estética orofacial. A síntese foi organizada por plano anatômico e integrada em um modelo clínico de raciocínio. Discussão: As evidências indicam que o envelhecimento facial não resulta de falha isolada da pele ou de simples descida gravitacional, mas da interação entre remodelamento esquelético, deflação e redistribuição de gordura, sistemas de retenção, musculatura e matriz dérmica. A organização por camadas permite correlacionar alterações anatômicas com modalidades terapêuticas empregadas na HOF, na CEOF e na CTBMF. Conclusão: O envelhecimento facial deve ser compreendido como fenômeno multicamadas, interdependente e individualizado. Este modelo favorece planejamento terapêutico estratificado, no qual procedimentos minimamente invasivos, cirúrgicos e estruturais são indicados conforme o plano anatômico predominante de alteração.
Referências
1. Gonzalez-Ulloa M, Flores ES. Senility of the face: basic study to understand its causes and effects. Plast Reconstr Surg. 1965;36(2):239-246.
2. Cotofana S, Fratila AAM, Schenck TL, Redka-Swoboda W, Zilinsky I, Pavicic T. The anatomy of the aging face: a review. Facial Plast Surg. 2016;32(3):253-260. doi:10.1055/s-0036-1582234.
3. Fitzgerald R, Graivier MH, Kane M, Lorenc ZP, Vleggaar D, Werschler WP, et al. Update on facial aging. Aesthet Surg J. 2010;30(Suppl 1):11S-24S. doi:10.1177/1090820X10378696.
4. Freytag L, Alfertshofer MG, Frank K, Moellhoff N, Helm S, Redaelli A, et al. Understanding facial aging through facial biomechanics: a clinically applicable guide for improved outcomes. Facial Plast Surg Clin North Am. 2022;30(2):125-133. doi:10.1016/j.fsc.2022.01.001.
5. Furnas DW. The retaining ligaments of the cheek. Plast Reconstr Surg. 1989;83(1):11-16.
6. Mendelson BC. Surgery of the superficial musculoaponeurotic system: principles of release, vectors, and fixation. Plast Reconstr Surg. 2001;107(6):1545-1552; discussion 1553-1555.
7. Lambros V. Observations on periorbital and midface aging. Plast Reconstr Surg. 2007;120(5):1367-1376. doi:10.1097/01.prs.0000279348.09156.c3.
8. Pessa JE. An algorithm of facial aging: verification of Lambros’s theory by three-dimensional stereolithography, with reference to the pathogenesis of midfacial aging, scleral show, and the lateral suborbital trough deformity. Plast Reconstr Surg. 2000;106(2):479-488.
9. Pessa JE, Zadoo VP, Yuan C, Ayedelotte JD, Cuellar FJ, Cochran CS, et al. Concertina effect and facial aging: nonlinear aspects of youthfulness and skeletal remodeling, and why, perhaps, infants have jowls. Plast Reconstr Surg. 1999;103(2):635-644.
10. Pessa JE, Zadoo VP, Mutimer KL, Haffner C, Yuan C, DeWitt AI, et al. Relative maxillary retrusion as a natural consequence of aging: combining skeletal and soft-tissue changes into an integrated model of midfacial aging. Plast Reconstr Surg. 1998;102(1):205-212.
11. Pessa JE, Desvigne LD, Lambros VS, Nimerick J, Sugunan B, Zadoo VP. Changes in ocular globe-to-orbital rim position with age: implications for aesthetic blepharoplasty of the lower eyelids. Aesthetic Plast Surg. 1999;23(5):337-342.
12. Kahn DM, Shaw RB Jr. Aging of the bony orbit: a three-dimensional computed tomographic study. Aesthet Surg J. 2008;28(3):258-264.
13. Shaw RB Jr, Katzel EB, Koltz PF, Yaremchuk MJ, Girotto JA, Kahn DM, et al. Aging of the facial skeleton: aesthetic implications and rejuvenation strategies. Plast Reconstr Surg. 2011;127(1):374-383. doi:10.1097/PRS.0b013e3181f95b2d.
14. Shaw RB Jr, Katzel EB, Koltz PF, Kahn DM, Girotto JA, Langstein HN. Aging of the mandible and its aesthetic implications. Plast Reconstr Surg. 2010;125(1):332-342. doi:10.1097/PRS.0b013e3181c2a685.
15. Mendelson B, Wong CH. Changes in the facial skeleton with aging: implications and clinical applications in facial rejuvenation. Aesthetic Plast Surg. 2012;36(4):753-760. doi:10.1007/s00266-012-9904-3.
16. Rohrich RJ, Pessa JE. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plast Reconstr Surg. 2007;119(7):2219-2227. doi:10.1097/01.prs.0000265403.66886.54.
17. Rohrich RJ, Pessa JE. The retaining system of the face: histologic evaluation of the septal boundaries of the subcutaneous fat compartments. Plast Reconstr Surg. 2008;121(5):1804-1809. doi:10.1097/PRS.0b013e31816c3c1a.
18. Rohrich RJ, Pessa JE, Ristow B. The youthful cheek and the deep medial fat compartment. Plast Reconstr Surg. 2008;121(6):2107-2112. doi:10.1097/PRS.0b013e31817123c6.
19. Gierloff M, Stohring C, Buder T, Gassling V, Acil Y, Wiltfang J. Aging changes of the midfacial fat compartments: a computed tomographic study. Plast Reconstr Surg. 2012;129(1):263-273. doi:10.1097/PRS.0b013e3182362b96.
20. Cotofana S, Lachman N. Anatomy of the facial fat compartments and their relevance in aesthetic surgery. J Dtsch Dermatol Ges. 2019;17(4):399-413. doi:10.1111/ddg.13737.
21. Rohrich RJ, Avashia YJ, Savetsky IL. Prediction of facial aging using the facial fat compartments. Plast Reconstr Surg. 2021;147(1S-2):38S-42S. doi:10.1097/PRS.0000000000007624.
22. Galanin I, Nicu C, Tower JI. Facial fat fitness: a new paradigm to understand facial aging and aesthetics. Aesthetic Plast Surg. 2021;45(1):151-163. doi:10.1007/s00266-020-01933-6.
23. Le Louarn C, Buthiau D, Buis J. Structural aging: the facial recurve concept. Aesthetic Plast Surg. 2007;31(3):213-218. doi:10.1007/s00266-006-0024-9.
24. Coleman SR, Grover R. The anatomy of the aging face: volume loss and changes in 3-dimensional topography. Aesthet Surg J. 2006;26(1 Suppl):S4-S9.
25. Donofrio LM. Fat distribution: a morphologic study of the aging face. Dermatol Surg. 2000;26(12):1107-1112.
26. Rohrich RJ, Ghavami A, Lemmon JA, Brown SA. The individualized component face lift: developing a systematic approach to facial rejuvenation. Plast Reconstr Surg. 2009;123(3):1050-1063. doi:10.1097/PRS.0b013e31819c91b0.
27. Fisher GJ, Varani J, Voorhees JJ. Looking older: fibroblast collapse and therapeutic implications. Arch Dermatol. 2008;144(5):666-672. doi:10.1001/archderm.144.5.666.
28. Quan T, Fisher GJ. Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging. Gerontology. 2015;61(5):427-434.
29. Rabe JH, Mamelak AJ, McElgunn PJS, Morison WL, Sauder DN. Photoaging: mechanisms and repair. J Am Acad Dermatol. 2006;55(1):1-19. doi:10.1016/j.jaad.2005.05.010.
30. Schmid-Wendtner MH, Korting HC. The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol. 2006;19(6):296-302. doi:10.1159/000094670.
31. Beaini TL, Cappellette Jr M, Melani RFH. Facial pattern analysis: critic review and collection of facial proportions in a Brazilian sample using cone-beam computed tomography. Biosci J. 2017;33(5):1389-1400.
32. Sundaram H, Signorini M, Liew S, de Almeida ART, Wu Y, Braz AV, et al. Global aesthetics consensus: botulinum toxin type A-evidence-based review, emerging concepts, and consensus recommendations for aesthetic use, including updates on complications. Plast Reconstr Surg. 2016;137(3):518e-529e. doi:10.1097/01.prs.0000475758.63709.23.
33. Sundaram H, Liew S, Signorini M, Braz AV, Fagien S, Swift A, et al. Global aesthetics consensus: hyaluronic acid fillers and botulinum toxin type A-recommendations for combined treatment and optimizing outcomes in diverse patient populations. Plast Reconstr Surg. 2016;137(5):1410-1423. doi:10.1097/PRS.0000000000002119.
34. van Loghem J, Yutskovskaya YA, Werschler WP. Calcium hydroxylapatite: over a decade of clinical experience. J Clin Aesthet Dermatol. 2015;8(1):38-49.
35. de Almeida AT, Figueredo V, da Cunha ALG, Casabona G, Faria JRC, Alves EV, et al. Consensus recommendations for the use of hyperdiluted calcium hydroxyapatite as a face and body biostimulatory agent. Plast Reconstr Surg Glob Open. 2019;7(3):e2160. doi:10.1097/GOX.0000000000002160.
36. Ao YJ, Yi Y, Wu GH. Application of PLLA (Poly-L-Lactic acid) for rejuvenation and reproduction of facial cutaneous tissue in aesthetics: a review. Medicine (Baltimore). 2024;103(11):e37506. doi:10.1097/MD.0000000000037506.
37. Cure E, Parra Hernandez LA, Martinez Amado A, Rodriguez Cabrales JS, Garces E, Dicker V, et al. Optimizing collagen biostimulator choice in LATAM: expert consensus on patient selection, ethnic skin phenotypes, and accessibility. J Cosmet Dermatol. 2025;24:e70564. doi:10.1111/jocd.70564.
38. Soleymani T, Lanoue J, Rahman Z. A practical approach to chemical peels: a review of fundamentals and step-by-step algorithmic protocol for treatment. J Clin Aesthet Dermatol. 2018;11(8):21-28.
39. Morris MX, Gebhardt S, Tingen JN, Dorante MI, Pandya S. Laser resurfacing versus chemical peels: a review of current trends and technological advances in nonsurgical facial rejuvenation. J Aesthetic Med. 2025;1:5. doi:10.3390/jaestheticmed1010005.
40. Petrov A. Efficiency of carbon dioxide fractional laser in skin resurfacing. Open Access Maced J Med Sci. 2016;4(2):271-276. doi:10.3889/oamjms.2016.062.
41. Foppiani JA, Fanning JE, Beltran K, Raska O, Hernandez Alvarez A, Taritsa I, et al. Microneedling for facial rejuvenation: a systematic review. Aesthetic Plast Surg. 2025;49(17):4949-4960. doi:10.1007/s00266-025-04972-z.
42. Neri JSV, Souza DAS, Dantas JBL, Lima AAM, Silva AM. Aplicação do ultrassom microfocado no rejuvenescimento facial: uma revisão da literatura. Int J Sci Dent. 2023;30(60):137-146. doi:10.22409/ijosd.v1i60.54172.
43. Li X, Xie G, Yang Z, Li S, Liao X, Lu J, et al. Evaluating the long-term effects of microfocused ultrasound on facial tightening using quantitative instruments: efficacy and safety. Aesthetic Plast Surg. 2026;50:692-706. doi:10.1007/s00266-025-05205-z.
44. Kumar N, Suh DH, Lee SJ, Ryu HJ. Radiofrequency-based treatments for facial rejuvenation: a systematic review of efficacy, safety, and patient-centered outcomes. Aesthet Surg J Open Forum. 2025;7:ojaf159. doi:10.1093/asjof/ojaf159.
45. Germani M, Munoz-Lora VRM, Carnevali ACN, Geroldo AM, Teixeira FF, Giro G. Is more always better? A randomized comparative clinical trial about the impact of polydioxanone threads quantity for facial lifting. Aesthet Surg J Open Forum. 2025;7:ojaf002. doi:10.1093/asjof/ojaf002.
46. Cohen SR, Womack H. Injectable tissue replacement and regeneration: anatomic fat grafting to restore decayed facial tissues. Plast Reconstr Surg Glob Open. 2019;7(8):e2293. doi:10.1097/GOX.0000000000002293.
47. Sadati K, Motakef S. Triple-C SMAS plication facelift for natural facial rejuvenation. Plast Reconstr Surg Glob Open. 2019;7(12):e2575. doi:10.1097/GOX.0000000000002575.
48. Gimenez AR, Rohrich R, Borab Z, Fisher S, Fagien S, Rohrich RJ. Safety and complications in lower eyelid blepharoplasty: a systematic review. Plast Reconstr Surg Glob Open. 2025;13:e7102. doi:10.1097/GOX.0000000000007102.
49. Khoury S, Almubarak Z, Khan H, Boldt G, Villemure-Poliquin N, Nichols AC. The deep plane versus SMAS facelift: a systematic review and meta-analysis. Aesthetic Plast Surg. 2025;49:5895-5903. doi:10.1007/s00266-025-05118-x.
50. Denadai R, Chou PY, Su YY, Lo CC, Lin HH, Ho CT, et al. Facial appearance and psychosocial features in orthognathic surgery: a FACE-Q- and 3D facial image-based comparative study of patient-, clinician-, and lay-observer-reported outcomes. J Clin Med. 2019;8(6):909. doi:10.3390/jcm8060909.
51. Kim YJ, Kim MY, Jha N, Jung MH, Kwon YD, Shin HG, et al. Treatment outcome and long-term stability of orthognathic surgery for facial asymmetry: a systematic review and meta-analysis. Korean J Orthod. 2024;54(2):89-107. doi:10.4041/kjod23.194.
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